STATS AND STUFF: San Francisco is starting the season with back-to-back road games for the 13th time in franchise history. … 49ers QB Brock Purdy did not play in the two games against the Rams last season. They worked together for four seasons with Washington 2010-2013. … Including the playoffs, Kyle Shanahan is 9-4 against Sean McVay.
49ERS VS RAMS PLAY BY PLAY SERIES
The Rams’ only victory in the series since 2019 came in the NFC championship game on Jan. SERIES NOTES: San Francisco has won eight straight regular-season games against Los Angeles.
Brett Rypien will be Stafford’s backup for at least the next four weeks. Rams rookie QB Stetson Bennett was placed on the non-football injury list Wednesday for undisclosed reasons. KEY INJURIES: 49ers LB Dre Greenlaw is dealing with a hamstring injury but is expected to play. Drake Jackson had three sacks to match his entire rookie season in 2022 and created considerable pressure off left tackle, which means Alaric Jackson in particular will be tested. Los Angeles will need an equally effective performance against a San Francisco defensive front that picked up five sacks and nine quarterback hits in a romp over the Steelers. Matthew Stafford was kept clean versus the Seahawks and threw for 334 yards without an interception.
Since starter Cam Akers struggled to get going in the season opener, with nine of his 22 carries going for no gain or a loss, Williams can make his case for a larger role by putting together another strong showing. RAMS PLAYER TO WATCH: RB Kyren Williams ran for 52 yards and his first two NFL touchdowns in the win over Seattle.
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